Results
| PMID | 23799909 |
| Gene Name | PON1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 80 |
| Population details | 80 (33 mild endometriosis, 47 moderate/severe endometriosis) |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
|
Reprod Health. 2013 Jun 22;10:32. doi: 10.1186/1742-4755-10-32. Bragatto, Felipe Barca| Barbosa, Caio Parente| Christofolini, Denise Maria| Peluso, Carla| dos Santos, Aline Amaro| Mafra, Fernanda Abani| Cavalcanti, Viviane| Hix, Sonia| Bianco, Bianca Division of Biochemistry, Department of Morphology, Faculdade de Medicina do ABC, Santo Andre, Santo Andre/SP, Brazil. BACKGROUND: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe). METHODS: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined. RESULTS: The paraoxonase activity were 191.29 +/- 22.41 U/l in women with minimal/mild endometriosis and 224.85 +/- 21.50 U/l in women with moderate/severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 +/- 4.61 U/l in women with minimal/mild endometriosis and 90.78 +/- 3.43 U/l in moderate/severe disease (P = 0.888). CONCLUSIONS: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis. Mesh Terms: Adult| Aryldialkylphosphatase/*blood| Endometriosis/*blood/complications/pathology| Female| Humans| Infertility, Female/complications| Oxidative Stress|DA 2013/11/10 06:00 |
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